Ruanbin Wang, Feng Gu, Shuhao Yan, Yonggang Zhao, Li-Qian Cheng. Preparation and properties of artificial bone with lead-free piezoelectric materials[J]. Materials Lab, 2023, 2(3): 230005. doi: 10.54227/mlab.20230005
Citation: Ruanbin Wang, Feng Gu, Shuhao Yan, Yonggang Zhao, Li-Qian Cheng. Preparation and properties of artificial bone with lead-free piezoelectric materials[J]. Materials Lab, 2023, 2(3): 230005. doi: 10.54227/mlab.20230005

RESEARCH ARTICLE

Preparation and properties of artificial bone with lead-free piezoelectric materials

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  • Corresponding author: chenglq@cumtb.edu.cn
  • In order to fabricate the artificial bone with high bioactive property, lead-free barium titanate (BaTiO3, BT) piezoelectric material added hydroxyapatite (HA) composites were prepared in this study. Compared with the pure HA materials, the introduction of BT can increase the electrical properties of the samples while ensuring good biological properties. The electrical properties, such as piezoelectric constant d33, hysteresis loop and dielectric spectrum were measured, respectively. The bending strength, Vickers hardness, cytotoxicity and osteogenic property of the BT/HA composites were also discussed. It is revealed that the non-toxic sample with 95 wt% BT and 5 wt% HA (95BT+5HA) has the best osteoinductivity, the piezoelectric constant d33 of which is 79.2 pC N−1. The bending strength and Vickers hardness of the 95BT+5HA sample are 138.3 MPa and 472.4, respectively, realizing the desired mechanical properties of human bones. Comprehensive analyses of various properties show that the 95BT+5HA composite can meet the requirements of artificial bone, and is expected to be a promising generation of substitute bone materials.


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  • 1. J. Lu, Z. Wang, H. Zhang, Y. Yang, X. Zheng and J. Xu, Tissue Eng. Part B, 2022, 28, 35
    2. D. Huten, G. Pasquier and J.-C. Lambotte, Orthop. Traumatol.: Surg. Res., 2021, 107, 102776
    3. R. Lanza, D. W. Russell and A. Nagy, Nat. Rev. Immunol., 2019, 19, 723
    4. R. Emadi, F. Tavangarian, S. I. R. Esfahani, A. Sheikhhosseini and M. Kharaziha, J. Am. Ceram. Soc., 2010, 93, 2679
    5. J. Zhang, Y. Feng, X. Zhou, Y. Shi and L. Wang, Int. J. Polym. Mater. Polym. Biomater., 2021, 70, 37
    6. Z. Xie, M. Gao, A. O. Lobo and T. J. Webster, Polymers, 2020, 12, 1717
    7. C. Cen, Y. Zhang, C. Luo, J. Wu, F. Liu and S. Wu, J. Pract. Orthop., 2019, 25, 326−332, 365
    8. Y. Noyama, T. Nakano, T. Ishimoto, T. Sakai and H. Yoshikawa, Bone, 2013, 52, 659
    9. N. Diomidis, S. Mischler, N. S. More and M. Roy, Acta Biomater., 2012, 8, 852
    10. A. M. Ferreira, P. Gentile, V. Chiono and G. Ciardelli, Acta Biomater., 2012, 8, 3191
    11. C. Hu, B. Qiu, Z. Zhou, Y. Yang and J. Li, Chin. J. Tissue. Eng. Res., 2020, 24, 589
    12. A. Dey, S. K. Nandi, B. Kumar, C. Kumar, P. Mukherjee, S. Roy, A. K. Mukhopadhyay, M. K. Sinha and D. Basu, Ceram. Int., 2011, 37, 1377
    13. F. Scalera, A. Quarta, D. M. Tobaldi R. C. Pullar and C. Piccirillo, Mater. Chem. Front., 2021, 5, 5071
    14. Y.-H Kim, H.-J. Lee, K.-A. Cho, J. Kim, J.-W. Park, S.-Y. Woo and K.-H. Ryu, Tissue Eng. Regener. Med., 2022, 19, 131
    15. M. Alipour, N. Firouzi, Z. Aghazadeh M. Samiei, S. Montazersaheb, A. B. Khoshfetrat and M. Aghazadeh, BMC Biotechnol., 2021, 21, 6
    16. S. Swain, R. N. Padhy and T. R. Rautray, J. Korean Ceram. Soc., 2020, 57, 495−502
    17. C Wu, Y. Tang, K. Zhao, M. Jiao and Z. Wu, Micro Nano Lett., 2020, 15, 421
    18. S. Swain, R. N. Padhy, and T. R. Rautray, Mater. Chem. Phys., 2020, 239, 122002
    19. A. Carter, K. Popowski, K. Cheng, A. Greenbaum, F. S. Ligler and A. Moatti, Bioelectricity, 2021, 3, 255
    20. L. F. George and E. A. Bates, Front. Cell Dev. Biol., 2022, 10, 772230
    21. L. Zhu, Y. Tang, M. Mao, Z. Wu and K. Zhao, J. Eur. Ceram. Soc., 2021, 41, 2775
    22. T. Kocabas, D. Cakir and C. Sevik, J. Phys. Condens. Matter, 2021, 33, 115705
    23. B. C. Wu, E. F. Haney, N. Akhoundsadegh, D. Pletzer, M. J. Trimble, A. E. Adriaans, P. H. Nibbering and R. E. Hancock, NPJ Biofilms Microbiomes, 2021, 7, 987
    24. M. Ren, Y. Zhao, Z. He, J. Lin, C. Xu, F. Liu, R. Hu, H. Deng and Y. Wang, BMC Complement. Med. Ther., 2021, 21, 43
    25. M. Parodi, R. Meazza, C. Vitale, G. Pietra, P. Carrega and M. Vitale, Methods Mol. Biol., 2019, 1884, 87
    26. D. Omagari, M. Hayatsu, K. Yamamoto, M. Kobayashi, N. Tsukano, M. Nameta and Y. Mikami, Bone, 2020, 141, 115596
    27. T. Balbaied, A. Hogan and E. Moore, Biosensors, 2020, 10, 95
    28. T. Balbaied and E. Moore, Appl. Sci., 2020, 10, 66
    29. H. Zarkoob, S. Ziaei-Rad, M. Fathi and H. Dadkhah, Adv. Eng. Mater., 2012, 14, B322
    30. T. Bian, H. Zhang and H. Xing, Colloids Surf, Colloids Surf. A, 2020, 602, 124802
    31. Y. Jia, L. Qin, Y. Gong, R. Chen, Y. Yang, W. Yang and K. Cai, J. Biomed. Mater. Res. Part A, 2020, 109, 804
    32. N. S. D. Vincentis, A Roatta, R. E. Bolmaro and J. W. Signorelli, Mater. Res., 2019, 22, e20180412
    33. A. L. Hong, M. Ispiryan, M. V. Padalkar, B. C. Jones, A. S. Batzdorf, S. S. Shetye, N. Pleshko and C. S. Rajapakse, Bone Rep., 2019, 11, 100213
    34. X. He, F. Han, M. Liu, Z. Yuan, X. Jiang, C. Hu, S. Ren, X, Lei and L. Liu, J. Electron. Mater., 2020, 49, 6643
    35. R. Zafar and N. Gupta, IET Nanodielectr., 2020, 3, 53
    36. Z. Wang, P. Chen, W. Shi, Y. Li, D. Li, L. Zhang, Y. Yan, Y. Wang, H. Peng, Q. Li and G. Liu, J. Electroceram., 2019, 43, 96
    37. D. Singh, A. Dixit and P. S. Dobal, Ferroelectrics, 2021, 573, 63
    38. K. K. Rahangdale and S. Ganguly, Mater. Chem. Phys., 2021, 260, 124114
    39. Y. I. Dzhezherya, W. Xu, S. V. Cherepov, Y. B. Skirta, V. M. Kalita, A. V. Bodnaruk, N. A. Liedienov, A. V. Pashchenko, I. V. Fesych, B. Liu and G. G. Levchenko, Mater. Des., 2021, 197, 109281
    40. H. Roozbahani, M. Alizadeh, S. Ustinov and H. Handroos, J. Biomech., 2020, 114, 110157
    41. N. Jaouedi, F. J. Perales, J. M. Buades, N. Boujnah and M. S. Bouhlel, Sensors, 2020, 20, 4944
    42. B. Kwom and S. Lee, Appl. Sci., 2020, 10, 4849
    43. R. W. Mann, S. Labrash and S. Lozanoff, Hawaii J. Health Soc. Welf., 2020, 79, 202.
    44. E.-M. Chen, L. Sun, G.-P. Xu, X.-F. Zhang, World J. Stem cells, 2020, 12, 339
    45. S. Swetlana, N. Khatavkar and A. K. SSingh, J. Mater. Sci., 2020, 55, 15845
    46. B Hościło and K. L. Molski, Materials, 2020, 13, 4844
    47. R. F. B. D. Souza, F. C. B. D. Souza, A. Thorpe, D. Mantovani, K. C. Popat and Â. M. Moraes, Int. J. Biol. Macromol., 2020, 143, 619
    48. J. Xu, Y. Rao, X. Wu, J. Jiang, M. Yu, X. Chen and H. Wang, Dent. Mater. J., 2019, 38, 981
    49. Y. Ma, Y. Li, J. Hao, B. Ma, T. Di and H. Dong, Biomed. Mater. Eng., 2019, 30, 23
    50. M. S. Krasnov, A. I. Shaikhaliev, E. V. Korshakov, M. V. Efimenko, P. P. Soloshenkov, T. R. Davidova, N. D. Zvukova, E. S. Sinitskaya, V. P. Yamskova, I. A. Yamskov and V. I. Lozinsky, Bull. Exp. Bio. Med., 2019, 168, 457
    51. H. Jeon, S. Yun, E. Choi, D. Kang, K.-H. Park, D. Kim, S. Jin, J.-H. Shim, W.-S. Yun and J. Park, J. Ind. Eng. Chem., 2019, 79, 41
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