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Hongjie Du, Fanyu Yuan, Wenwen Qi, Fangyuan Zhu, Jian Liu, Chengzhilin Li, Zishuo Guo, Zhaoze Yang, Xu Guo, Chengcheng Liu, Ming Xia. Research advances in nasal epithelial organoids and challenges in clinical disease applications[J]. Materials Lab, 2025, 4(3): 250004. doi: 10.54227/mlab.20250004
Citation: Hongjie Du, Fanyu Yuan, Wenwen Qi, Fangyuan Zhu, Jian Liu, Chengzhilin Li, Zishuo Guo, Zhaoze Yang, Xu Guo, Chengcheng Liu, Ming Xia. Research advances in nasal epithelial organoids and challenges in clinical disease applications[J]. Materials Lab, 2025, 4(3): 250004. doi: 10.54227/mlab.20250004
shu

REVIEW ARTICLE

Research advances in nasal epithelial organoids and challenges in clinical disease applications

More Information
  • 1.

    Department of Otolaryngology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jingwu Weiqi Road, 250033, China

  • 2.

    Department of Central Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University,544 Jingsi Road, 250033, China

  • 3.

    Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China

  • 4.

    NHC Key Laboratory of Otorhinolaryngology,107 Wenhua West Road, China

  • 5.

    Shandong Second Medical University, Baotong West Street, Weifang, Shandong, 261053, China

  • Corresponding authors: LCcheng211314@126.com; xiamingsdu@sohu.com

    • § These authors have contributed equally to this work.

    Abstract

  • Organoids, as a novel type of 3D spherical model, possess characteristics such as tissue heterogeneity, functional simulation capability, scalability, personalization, and strong compatibility. These features endow them with significant advantages in drug testing, including the ability to highly simulate human physiological and pathological characteristics, strong clinical relevance, high-throughput and rapid screening capabilities, avoidance of the limitations of animal models, and potential for personalized treatment. As a result, organoids have become an essential tool in drug development and precision medicine.In recent years, nasal organoids have been preliminarily established. These models have been utilized to elucidate the pathogenesis of chronic and acute sinusitis through nasal organoid inflammation models, as well as to screen allergens in allergic rhinitis. Additionally, olfactory epithelial organoid models have been employed to study the mechanisms of olfactory neuron damage and regeneration. This article reviews the recent advances in the fundamental research of nasal organoids and innovatively outlines a composite culture medium formulation developed by our laboratory, providing a new technical approach for cost-effective and efficient organoid research.


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    • Author Biographies
  • Du Hongjie has been pursuing his Ph.D. at Shandong First Medical University since 2024, under the supervision of Professor Xia Ming. His research focuses on investigating the pathogenesis of allergic rhinitis and chronic rhinosinusitis.
    Liu Chengcheng is an Associate Researcher and Chief Technologist at the Provincial Hospital affiliated with Shandong First Medical University, as well as a Doctoral Supervisor and Professor at Shandong First Medical University. He obtained his Ph.D. from Shandong University in 2017 and conducted postdoctoral research there in 2018. In 2020, he joined the Provincial Hospital affiliated with Shandong First Medical University. In 2023, he was honored with the title of Outstanding Young Innovation Team Leader. He serves as an editorial board member for journals such as Sensory Neuroscience. His primary research focuses on olfactory disorders and the pathogenic mechanisms of allergic rhinitis.
    Xia Ming is a Chief Physician at the Provincial Hospital affiliated with Shandong First Medical University, a doctoral supervisor, and a researcher. He obtained his Ph.D. from Shandong University in 2008. In 2018, he was honored as a Shandong Taishan Scholar Young Expert. He serves as an editorial board member for journals such as Flavour and Fragrance Journal and the Chinese Journal of Medical Science Research Management. His primary research focuses on the pathogenic mechanisms of chronic rhinosinusitis, allergic rhinitis, and age-related hearing loss.
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Received Date:  07 April 2025
Revised Date:  30 April 2025
Accepted Date:  08 May 2025
Available Online:  09 May 2025
Publish Date:  30 December 2025

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